Sample questions / Gastrointestinal & Hepatobiliary
Organ system
Gastrointestinal & Hepatobiliary questions for Step 1
Work through gastrointestinal & hepatobiliary vignettes that mix physiology, pathology and pharmacology, the way the exam does. Every explanation covers all five options.
PhysiologyMedium
Malnutrition in cirrhosis
A 46-year-old man with alcoholic cirrhosis has marked muscle wasting despite adequate calories. Albumin is 2.8; he is fatigued and has ascites and edema.
What contributes most to protein-energy malnutrition in cirrhosis?
- Decreased cytokine production
- Hypermetabolism with altered fuel utilization
- Decreased protein requirements
- Enhanced protein synthesis
- Improved branched-chain amino acid metabolism
MicrobiologyEasy
Typhoid fever serology
A 25-year-old woman back from South Asia has a stepwise rising fever, relative bradycardia, rose spots and hepatosplenomegaly. Blood cultures grow non-lactose-fermenting gram-negative rods that produce H2S.
Which serologic test supports the diagnosis?
- Cold agglutinins
- Monospot test
- Widal test
- ASO titer
- Weil-Felix test
PharmacologyEasy
Iron poisoning
Four hours after swallowing many iron tablets, a 3-year-old has severe belly pain, vomiting and bloody diarrhea.
What causes the GI injury?
- Decreased GI motility
- Allergic reaction to iron
- Bacterial overgrowth
- Osmotic diarrhea from unabsorbed iron
- Direct corrosive effect on GI mucosa
PathologyEasy
Familial adenomatous polyposis
Screening colonoscopy in a 45-year-old man finds twenty polyps scattered through the colon, all tubular adenomas on histology. His father died of colorectal cancer at 50.
Which gene is most likely mutated?
- MLH1
- PTEN
- STK11
- CDH1
- APC
BiochemistryEasy
Von Gierke disease
A 3-month-old has poor growth, a big liver and fasting hypoglycemia with lactic acidosis. Liver biopsy shows massive glycogen in hepatocytes.
Which enzyme is most likely deficient?
- Pyruvate kinase
- Glycogen synthase
- Phosphofructokinase
- Glucose-6-phosphatase
- Alpha-glucosidase
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