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Sample questions / Gastrointestinal & Hepatobiliary

Organ system

Gastrointestinal & Hepatobiliary questions for Step 1

Work through gastrointestinal & hepatobiliary vignettes that mix physiology, pathology and pharmacology, the way the exam does. Every explanation covers all five options.

PhysiologyMedium

Malnutrition in cirrhosis

A 46-year-old man with alcoholic cirrhosis has marked muscle wasting despite adequate calories. Albumin is 2.8; he is fatigued and has ascites and edema.

What contributes most to protein-energy malnutrition in cirrhosis?

  1. Decreased cytokine production
  2. Hypermetabolism with altered fuel utilization
  3. Decreased protein requirements
  4. Enhanced protein synthesis
  5. Improved branched-chain amino acid metabolism
MicrobiologyEasy

Typhoid fever serology

A 25-year-old woman back from South Asia has a stepwise rising fever, relative bradycardia, rose spots and hepatosplenomegaly. Blood cultures grow non-lactose-fermenting gram-negative rods that produce H2S.

Which serologic test supports the diagnosis?

  1. Cold agglutinins
  2. Monospot test
  3. Widal test
  4. ASO titer
  5. Weil-Felix test
PharmacologyEasy

Iron poisoning

Four hours after swallowing many iron tablets, a 3-year-old has severe belly pain, vomiting and bloody diarrhea.

What causes the GI injury?

  1. Decreased GI motility
  2. Allergic reaction to iron
  3. Bacterial overgrowth
  4. Osmotic diarrhea from unabsorbed iron
  5. Direct corrosive effect on GI mucosa
PathologyEasy

Familial adenomatous polyposis

Screening colonoscopy in a 45-year-old man finds twenty polyps scattered through the colon, all tubular adenomas on histology. His father died of colorectal cancer at 50.

Which gene is most likely mutated?

  1. MLH1
  2. PTEN
  3. STK11
  4. CDH1
  5. APC
BiochemistryEasy

Von Gierke disease

A 3-month-old has poor growth, a big liver and fasting hypoglycemia with lactic acidosis. Liver biopsy shows massive glycogen in hepatocytes.

Which enzyme is most likely deficient?

  1. Pyruvate kinase
  2. Glycogen synthase
  3. Phosphofructokinase
  4. Glucose-6-phosphatase
  5. Alpha-glucosidase

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